2-氯-3-(2-硝基苯甲酰氨基)吡啶合成路线 （共 7 条）
反应条件
pyridine T=0 - 20°C;
参考文献
SIRTRIS PHARMACEUTICALS, INC.
Patent: WO2009/61453 A1, 2009 ;
Location in patent: Page/Page column 65 ;
WO 2009/061453 A1
反应条件
1: oxalyl chloride; DMF / tetrahydrofuran / 1 h / Heating 2: 5.55 g / pyridine / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 17 p. 4300 - 4315
反应条件
1: 86 percent / aq. HCl; SnCl2 / 0.25 h / 100 °C 2: 80 percent / 0.08 h / 205 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 17 p. 4300 - 4315
反应条件
1: 86 percent / aq. HCl; SnCl2 / 0.25 h / 100 °C 2: 80 percent / 0.08 h / 205 °C 3: 70 percent / Et3N / dioxane / 8 h / Heating View Scheme
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
反应条件
sodium hydride in tetrahydrofuran
T=30 - 35°C; 12 h;
参考文献
Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina
Tetrahedron, 2005 , vol. 61, # 1 p. 61 - 68
反应条件
1: 82 percent / NaH / tetrahydrofuran / 12 h / 30 - 35 °C
2: 98 percent / AcOH; Fe dust / ethanol / 5 h / Heating
View Scheme
参考文献
Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina
Tetrahedron, 2005 , vol. 61, # 1 p. 61 - 68
反应条件
hydrogenchloride; tin(ll) chloride
T=100°C; 0.25 h;
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
