2-甲氧基-3-溴-5-氯吡啶合成路线 （共 8 条）
反应条件
bromine; sodium acetate in acetic acid 1.) 80 deg C, 6 h, 2.) 23 deg C, 64 h;;
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 1583 - 1592
反应条件
1: 75 percent / methanol / 68 h / Heating 2: 74 percent / anhydrous sodium acetate, Br2 / acetic acid / 1.) 80 deg C, 6 h, 2.) 23 deg C, 64 h; View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 1583 - 1592
反应条件
1: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 15 min, 2.) THF, -65 deg C 2: 81 percent / 48percent HBr, HOAc / 0.25 h / 100 °C View Scheme
参考文献
Bargar, T. M.; Wilson, T.; Daniel, J. K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1583 - 1592
反应条件
1: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 15 min, 2.) THF, -65 deg C 2: 81 percent / 48percent HBr, HOAc / 0.25 h / 100 °C 3: 64 percent / H2 / W-2 Raney Ni / tetrahydrofuran; ethanol / 6 h View Scheme
参考文献
Bargar, T. M.; Wilson, T.; Daniel, J. K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1583 - 1592
反应条件
1: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 15 min, 2.) ether, hexane, THF, -65 deg C 2: 74 percent / 48percent HBr, HOAc / 0.25 h / 100 °C 3: 56 percent / H2 / W-2 Raney Ni / tetrahydrofuran; ethanol / 6 h View Scheme
参考文献
Bargar, T. M.; Wilson, T.; Daniel, J. K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1583 - 1592
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US4588733 A1, 1986 ;
反应条件
n-butyllithium 1.) ether, hexane, -70 deg C, 10 min, 2.) -55 to -70 deg C;; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bargar, T. M.; Wilson, T.; Daniel, J. K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1583 - 1592
反应条件
n-butyllithium
1.) ether, hexane, -70 deg C, 10 min, 2.) -55 to -70 deg C;; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bargar, T. M.; Wilson, T.; Daniel, J. K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1583 - 1592
