二乙基(Boc-氨基)乙酯合成路线 （共 11 条）
参考文献
David, Katerine; Cazes, Bernard; Gore, Jacques
Journal of Chemical Research, Miniprint, 1996 , # 11 p. 2768 - 2792
反应条件
sodium hydrogencarbonate; sodium chloride in chloroform; water 12 h; Heating;
参考文献
Paik, Yi Hyon; Dowd, Paul
Journal of Organic Chemistry, 1986 , vol. 51, # 15 p. 2910 - 2913
反应条件
1: 10.8 g / 1 M aq. NaOH / dioxane / Ambient temperature 2: 85 percent / 1.6 M BuLi / tetrahydrofuran; hexane / 2 h / -80 - -50 °C View Scheme
参考文献
Schmidt; Griesser; Lieberknecht; Grather
Synthesis, 1993 , # 8 p. 765 - 766
反应条件
1: 80.5 percent / sodium / ethanol / 4 h / Heating 2: 83.3 percent / 1N NaOH / ethanol / 16 h / 20 °C 3: 89.8 percent / xylene / 2 h / Heating 4: 95.8 percent / 24 h / 37 °C / α-chymotrypsin, 1N NaOH, 0.1M phosphate buffer, pH 7.5-8 View Scheme
参考文献
Schneider, Helmut; Sigmund, Gerhard; Schricker, Bettina; Thirring, Klaus; Berner, Heinz
Journal of Organic Chemistry, 1993 , vol. 58, # 3 p. 683 - 689
反应条件
1.1: NaH / dimethylformamide; hexane / 2 h / 20 °C 1.2: dimethylformamide; hexane / 2 h / 20 °C 2.1: aq. AcOH / 16 h / pH 5 / Heating 2.2: Alcalase 2.4L; aq. NaHCO3 / 2.5 h / 25 - 27 °C View Scheme
参考文献
Greenspan; Clark; Tommasi; Cowen; McQuire; Farley; Van Duzer; Goldberg; Zhou; Du; Fitt; Coppa; Fang; Macchia; Zhu; Capparelli; Goldstein; Wigg; Doughty; Bohacek; Knap
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4524 - 4534
参考文献
Shapiro, Rafael
Journal of Organic Chemistry, 1993 , vol. 58, # 21 p. 5759 - 5764
反应条件
1.1: NaH / dimethylformamide; hexane / 2 h / 20 °C 1.2: dimethylformamide; hexane / 2 h / 20 °C 2.1: aq. AcOH / 16 h / pH 5 / Heating 2.2: Alcalase 2.4L; aq. NaHCO3 / 2.5 h / 25 - 27 °C View Scheme
参考文献
Greenspan; Clark; Tommasi; Cowen; McQuire; Farley; Van Duzer; Goldberg; Zhou; Du; Fitt; Coppa; Fang; Macchia; Zhu; Capparelli; Goldstein; Wigg; Doughty; Bohacek; Knap
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4524 - 4534
反应条件
potassium hydroxide in ethanol T=20°C; 2.5 h;
参考文献
Flipo, Marion; Beghyn, Terence; Charton, Julie; Leroux, Virginie A.; Deprez, Benoit P.; Deprez-Poulain, Rebecca F.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 63 - 76
反应条件
1.1: NaH / dimethylformamide; hexane / 2 h / 20 °C 1.2: dimethylformamide; hexane / 2 h / 20 °C 2.1: aq. AcOH / 16 h / pH 5 / Heating 2.2: 3.55 g / Alcalase 2.4L; aq. NaHCO3 / 2.5 h / 25 - 27 °C View Scheme
参考文献
Greenspan; Clark; Tommasi; Cowen; McQuire; Farley; Van Duzer; Goldberg; Zhou; Du; Fitt; Coppa; Fang; Macchia; Zhu; Capparelli; Goldstein; Wigg; Doughty; Bohacek; Knap
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4524 - 4534
反应条件
1.1: NaH / dimethylformamide; hexane / 2 h / 20 °C 1.2: dimethylformamide; hexane / 2 h / 20 °C 2.1: aq. AcOH / 16 h / pH 5 / Heating 2.2: Alcalase 2.4L; aq. NaHCO3 / 2.5 h / 25 - 27 °C View Scheme
参考文献
Greenspan; Clark; Tommasi; Cowen; McQuire; Farley; Van Duzer; Goldberg; Zhou; Du; Fitt; Coppa; Fang; Macchia; Zhu; Capparelli; Goldstein; Wigg; Doughty; Bohacek; Knap
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4524 - 4534
