2,4-二氯-6-甲基喹啉合成路线 （共 10 条）
反应条件
trichlorophosphate in 1,4-dioxane; dichloromethane; malonic acid
反应条件
trichlorophosphate 3 h; Heating;
参考文献
Osborne, Alan G.; Buley, Jill M.; Clarke, Helen; Dakin, Rachel C. H.; Price, Paul I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 22 p. 2747 - 2756
反应条件
in acetonitrile T=150°C; 12 h;
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: CuI; Et3N / PdCl2(PPh3)2 / tetrahydrofuran / 1 h / 20 °C 2: TBAF / tetrahydrofuran / 0 - 20 °C 3: 74 percent / acetonitrile / 12 h / 150 °C View Scheme
参考文献
Synlett, , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: aq. K2CO3 / methanol / 24 h / 50 °C 2: CuI; Et3N / PdCl2(PPh3)2 / tetrahydrofuran / 1 h / 20 °C 3: TBAF / tetrahydrofuran / 0 - 20 °C 4: 74 percent / acetonitrile / 12 h / 150 °C View Scheme
参考文献
Synlett, , # 1 art. no. U27905ST, p. 65 - 68
反应条件
sodium hydroxide 1 h; Ambient temperature;
参考文献
Ashok; Sridevi; Umadevi
Synthesis, 1993 , # 6 p. 623 - 626
反应条件
N,N-dimethyl-aniline; trichlorophosphate in toluene 3.5 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 15 p. 2761 - 2768
反应条件
1: TBAF / tetrahydrofuran / 0 - 20 °C 2: 74 percent / acetonitrile / 12 h / 150 °C View Scheme
参考文献
Synlett, , # 1 art. no. U27905ST, p. 65 - 68
反应条件
sodium methylate 1 h; Heating;
参考文献
Warner; Barker; Jackman; Burrows; Roberts; Bishop; O'Connor; Hughes
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2761 - 2768
反应条件
in methanol 25 h; Heating;
参考文献
Osborne, Alan G.; Dimitrova, Galya T.; Galbally, Paul; Hughes, David D.; Jones, Clare; Lipman, Anthony L.; Wilstead, Nicola
Journal of Chemical Research, Miniprint, 2002 , # 1 p. 124 - 148
