5-羟基-1,2,3,4-四氢异喹啉盐酸盐合成路线 （共 7 条）
反应条件
hydrogenchloride; hydrogen; platinum(IV) oxide in methanol P=2574.28 Torr; 3.5 h;
参考文献
Watanabe, Toshihiro; Kinoyama, Isao; Takizawa, Kenji; Hirano, Seiko; Shibanuma, Tadao
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 5 p. 672 - 677
反应条件
hydrogenchloride 20 h; Heating;
参考文献
Sall; Grunewald
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2208 - 2216
反应条件
1: 95 percent / K2CO3 / methanol; H2O / 12 h / Ambient temperature 2: 99 percent / 3 N aq. HCl / 20 h / Heating View Scheme
参考文献
Sall; Grunewald
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2208 - 2216
反应条件
1: 72 percent / Et3N / 10 h / Ambient temperature 2: 95 percent / K2CO3 / methanol; H2O / 12 h / Ambient temperature View Scheme
参考文献
Sall; Grunewald
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2208 - 2216
反应条件
1: 72 percent / Et3N / 10 h / Ambient temperature 2: 95 percent / K2CO3 / methanol; H2O / 12 h / Ambient temperature 3: 93 percent / K2CO3 / acetone / 12 h / Heating 4: 96 percent / 3 N aq. HCl / 20 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2208 - 2216
反应条件
triethylamine in 1,4-dioxane; water 18 h; Ambient temperature;
参考文献
Watanabe, Toshihiro; Kinoyama, Isao; Takizawa, Kenji; Hirano, Seiko; Shibanuma, Tadao
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 5 p. 672 - 677
参考文献
Heinonen; Petri; Lonnberg; Harri; Cockcroft; Victor
Patent: US5912342 A1, 1999 ;
