6-羟基-1,4-苯并二噁烷合成路线 （共 18 条）
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane T=50°C; 16 h;
参考文献
Roche Palo Alto LLC
Patent: US2007/49609 A1, 2007 ;
Location in patent: Page/Page column 102 ;
US 20070049609 A1
反应条件
sulfuric acid; sodium nitrite in water 1.) 0-5 deg C, 0.5 h; 2.) reflux, 0.5 h;
参考文献
Chapleo, Christopher B.; Doxey, John C.; Myers, Peter L.; Myers, Malcolm; Smith, Colin F. C.; Stillings, Michael R.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 619 - 622
反应条件
sodium hydroxide in methanol 3 h; Ambient temperature;
参考文献
Besson, Thierry; Ruiz, Nicolas; Coudert, Gerard; Guillaumet, Gerald
Tetrahedron, 1995 , vol. 51, # 11 p. 3197 - 3204
反应条件
potassium hydroxide in methanol T=20°C; 0.75 h;
参考文献
Hellberg, Jonas; Dahlstedt, Emma; Pelcman, Margit E.
Tetrahedron, 2004 , vol. 60, # 40 p. 8899 - 8912
反应条件
alpha-hydroxyethanoic acid; Cu(OH)2; sodium hydroxide in water; dimethyl sulfoxide T=120°C; 6 h; Inert atmosphereSchlenk technique;
参考文献
Xiao, Yan; Xu, Yongnan; Cheon, Hwan-Sung; Chae, Junghyun
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5804 - 5809
反应条件
Amberlyst-15 T=100°C; 6 h;
参考文献
Tetrahedron Letters, , vol. 55, # 1 p. 86 - 89
反应条件
1: potassium carbonate / acetone / 50 - 60 °C / Industry scale 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / Reflux; Industry scale View Scheme
参考文献
Biernacki, Wladyslaw; Sobotka, Wieslaw
Polish Journal of Chemistry, 1980 , vol. 54, # 11/12 p. 2239 - 2242
反应条件
1: 66.4 percent / Br2 / acetic acid 2: 1.) Mg / 1.) THF 3: 46.7 percent / 60 h / 145 °C View Scheme
参考文献
Polish Journal of Chemistry, , vol. 54, # 11/12 p. 2239 - 2242
反应条件
1: 57 percent / NaOH / dimethylsulfoxide 2: 66.4 percent / Br2 / acetic acid 3: 1.) Mg / 1.) THF 4: 46.7 percent / 60 h / 145 °C View Scheme
参考文献
Polish Journal of Chemistry, , vol. 54, # 11/12 p. 2239 - 2242
