3-(2-氨基苯基)-3-氧代丙腈合成路线 （共 8 条）
反应条件
hydrogen; platinum(IV) oxide in ethanol
参考文献
Sicker, D.; Wilde, H.
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1992 , vol. 334, # 1 p. 76 - 80
反应条件
1: 67 percent / H2O / 6 h / Heating 2: 81 percent / H2 / PtO2 / ethanol View Scheme
参考文献
Sicker, D.; Wilde, H.
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1992 , vol. 334, # 1 p. 76 - 80
反应条件
1: 1.) Na, EtOH / 1.) toluene, 90 deg C, 30 min, 2.) toluene, a) 20 deg C, 2 h, b) 100 deg C, 1 h 2: 67 percent / H2O / 6 h / Heating 3: 81 percent / H2 / PtO2 / ethanol View Scheme
参考文献
Sicker, D.; Wilde, H.
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1992 , vol. 334, # 1 p. 76 - 80
反应条件
in N,N-dimethyl-formamide 2 h; Ambient temperature;
参考文献
Alkhathlan, Hamad Z.; Al-Farhan, Khalid A.
Heterocycles, 1998 , vol. 48, # 4 p. 641 - 655
反应条件
1: 55 percent / concd HCl / ethanol / 2 h / 80 °C 2: 52 percent / dimethylformamide / 2 h / Ambient temperature View Scheme
参考文献
Alkhathlan, Hamad Z.; Al-Farhan, Khalid A.
Heterocycles, 1998 , vol. 48, # 4 p. 641 - 655
反应条件
1: 68 percent / CuBr2 / ethyl acetate; CHCl3 / 8 h / Heating 2: 55 percent / concd HCl / ethanol / 2 h / 80 °C 3: 52 percent / dimethylformamide / 2 h / Ambient temperature View Scheme
参考文献
Alkhathlan, Hamad Z.; Al-Farhan, Khalid A.
Heterocycles, 1998 , vol. 48, # 4 p. 641 - 655
反应条件
triethylamine; trifluoroacetic acid solid-phase synthesis; 1.) DMF, RT; 2.) 1 h; Yield given. Multistep reaction;
参考文献
Sim, Mui Mui; Lee, Cheng Leng; Ganesan
Tetrahedron Letters, 1998 , vol. 39, # 35 p. 6399 - 6402
反应条件
diethyl cyanophosphonate; benzotriazol-1-ol; triethylamine; trifluoroacetic acid; Wang resin; diisopropyl-carbodiimide 1.) DMF, 0 deg C, 12 h; 2.) THF; Yield given. Multistep reaction;
参考文献
Sim, Mui Mui; Lee, Cheng Leng; Ganesan
Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2195 - 2198
