3,4-二氢-2H-1,4-苯并嗪-2-甲胺合成路线 （共 4 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 0.5 h;
参考文献
ELI LILLY AND COMPANY; AGEJAS-CHICHARRO, Francisco Javier; DIAZ BUEZO, Nuria; GRUBER, Joseph Michael; STACK, Douglas Richard
Patent: WO2014/74365 A1, 2014 ;
Location in patent: Page/Page column 15 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=45°C; 36 h;
参考文献
Bourlot, Anne-Sophie; Sanchez, Isabel; Dureng, Georges; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Winslow, Eileen; Pujol, M. Dolors; Merour, Jean-Yves
Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3142 - 3158
反应条件
1: 25percent aq. NH3 / 12 h / Heating 2: 68 percent / LiAlH4 / tetrahydrofuran / 36 h / 45 °C View Scheme
参考文献
Bourlot, Anne-Sophie; Sanchez, Isabel; Dureng, Georges; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Winslow, Eileen; Pujol, M. Dolors; Merour, Jean-Yves
Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3142 - 3158
反应条件
1: potassium chloride / acetone / 16 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C View Scheme
参考文献
ELI LILLY AND COMPANY; AGEJAS-CHICHARRO, Francisco Javier; DIAZ BUEZO, Nuria; GRUBER, Joseph Michael; STACK, Douglas Richard
Patent: WO2014/74365 A1, 2014 ;
