(4S)-3,4-二氢-2-(3-甲氧基丙基)-2H-噻吩并[3,2-e]-1,2-噻嗪-4-醇 1,1-二氧化物合成路线 (共 2 条)
反应条件
potassium carbonate in acetone 48 h; Heating / reflux;
参考文献
WO2008/62463 A2, ;
Page/Page column 25 ;
反应条件
1: With sec.-butyllithium in tetrahydrofuran; cyclohexane T=-5 - 0°C; 8.75 h; Inert atmosphere; 2: With sulfur dioxide in tetrahydrofuran; cyclohexane T=-65 - 20°C; Inert atmosphere; 3: With NaOAc·3H2O; hydroxylamine-o-sulphonic acid in water T=0 - 20°C; Product distribution / selectivity;
参考文献
Sathe, Dhananjay Govind; Tarur, Radhakrishnan Venkatasubramanian; Bhise, Nandu Baban; Shinde, Ajit Bhaskar; Pardeshi, Santosh
Patent: US2010/9977 A1, 2010 ;
Location in patent: Page/Page column 11 ;