2-(3-氧代环戊基)异吲哚啉-1,3-二酮合成路线 （共 4 条）
反应条件
sodium carbonate in methanol; water T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: US2011/118326 A1, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogenchloride in 1,4-dioxane; acetic acid T=90 - 100°C; 36 h;
参考文献
Gavardinas, Konstantinos; Green, Jonathan Edward; Jadhav, Prabhakar Kondaji; Matthews, Donald Paul
Patent: US2010/69404 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 - 20 °C 2: hydrogenchloride / methanol / 2 h / |Reflux View Scheme
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
反应条件
1: acetic acid / 5 h / Reflux 2: hydrazine hydrate / ethanol; tetrahydrofuran / 22 h / 20 - 55 °C View Scheme
