(S)-[7-氰基-1,2,3,4-四氢环戊二烯并[b]吲哚-2-基]氨基甲酸异丙酯合成路线 (共 1 条)
反应条件
Multi-step reaction with 5 steps 1.1: hydrazine hydrate / ethanol; tetrahydrofuran / 22 h / 20 - 55 °C2.1: sodium hydrogencarbonate / water; tetrahydrofuran / 1 h / 20 °C3.1: Chiralcel OJ / methanol / Resolution of racemate4.1: zinc; zinc diacetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 18 h / 100 °C5.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C5.2: 4 h / 20 °C
参考文献
ELI LILLY AND COMPANY Patent: US2011/118326 A1, 2011 ;