4-乙基-7,8-二氢-4-羟基-1H-吡喃并[3,4-f]吲嗪-3,6,10(4H)-三酮合成路线 (共 27 条)
反应条件
toluene-4-sulfonic acid in toluene
参考文献
DAIICHI SEIYAKU CO., LTD.; KABUSHIKI KAISHA YAKULT HONSHA
Patent: EP220601 B1, 1991 ;
反应条件
iodine in N,N-dimethyl-formamide T=80°C; Friedlaender synthesis; 8 h; Inert atmosphere;
参考文献
Kuang, Yun-Yan; Niu, Jing-Ze; Chen, Fen-Er
Helvetica Chimica Acta, 2010 , vol. 93, # 10 p. 2094 - 2099
反应条件
1: 86 percent / conc. HCl, glacial AcOH / 4 h / Heating 2: 65 percent / H2 / 10percent Pd/C / ethanol / 20 h / 760 Torr View Scheme
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
1: 48 percent / 1.67 h / 120 - 160 °C 2: 32 percent / H2 / 10percent Pd/C / ethanol / 0.5 h / Ambient temperature View Scheme
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
toluene-4-sulfonic acid in toluene 8 h; Heating;
参考文献
Wani; Nicholas; Wall
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2358 - 2363
反应条件
T=120 - 160°C; 1.66667 h;
参考文献
Wani; Nicholas; Wall
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2358 - 2363
反应条件
toluene-4-sulfonic acid
1.) toluene, reflux, 15 min, 2.) toluene, reflux, 5 h; Yield given. Multistep reaction;
参考文献
Wani; Nicholas; Manikumar; Wall
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1774 - 1779