1,4-二氯二苯甲基-1,2,4-噻唑合成路线 （共 4 条）
反应条件
toluene-4-sulfonic acid in toluene Alkylation; 20 h; Heating;
参考文献
Katritzky, Alan R.; Yang, Baozhen; Pleynet, David P. M.; Wang, Jin
Heterocycles, 2000 , vol. 52, # 1 p. 203 - 214
反应条件
sodium hydride 1.) DMF, heating, 15 min, 2.) heating, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Jones, C. David; Winter, Mark A.; Hirsch, Kenneth S.; Stamm, Nancy; Taylor, Harold M.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 416 - 429
反应条件
in 1,4-dioxane Reflux;
参考文献
El Hage, Salome; Lajoie, Barbora; Feuillolay, Catherine; Roques, Christine; Baziard, Genevieve
Archiv der Pharmazie, 2011 , vol. 344, # 6 p. 402 - 410
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; Metallation; 2 h; 2: With iodine in tetrahydrofuran T=-78°C; Iodination; 4 h;
参考文献
Katritzky, Alan R.; Yang, Baozhen; Pleynet, David P. M.; Wang, Jin
Heterocycles, 2000 , vol. 52, # 1 p. 203 - 214
