反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0.5 h / -15 °C / Inert atmosphere
1.2: 5.5 h / -15 °C
1.3: 5 h / Inert atmosphere; Reflux
2.1: 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux
4.1: thionyl chloride / dichloromethane / 4 h / 20 °C
View Scheme
参考文献
Taladriz, Andrea; Healy, Alan; Flores Perez, Eddysson J.; Herrero Garcia, Vanessa; Rios Martinez, Carlos; Alkhaldi, Abdulsalam A. M.; Eze, Anthonius A.; Kaiser, Marcel; De Koning, Harry P.; Chana, Antonio; Dardonville, Christophe
Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2606 - 2622