potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in toluene 24 h; Heatingselectivity of esterification with different prim., sec. and tert. diacides; Product distribution;
1: 3-(benzyloxycarbonyl)propionic acid With sodium hydrogencarbonate; tetra-n-butyl-ammonium sulfate in dichloromethane; water T=0°C; 0.25 h; 2: chloromethyl chlorosulphate in dichloromethane; water T=0 - 20°C; 5.5 h;
参考文献
LES LABORATOIRES SERVIER
Patent: US2010/286225 A1, 2010 ;
Location in patent: Page/Page column 4 ;
