1-(2-羟乙基)哌嗪合成路线 （共 140 条）
反应条件
triethylamine in tetrahydrofuran T=0 - 20°C; 3.5 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/88029 A1, 2007 ;
Location in patent: Page/Page column 27 ;
US 20070088029 A1
反应条件
in acetonitrile T=25°C; Kinetics;
参考文献
Kim, Min-Young; Lee, Jae-In; Um, Ik-Hwan
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 4 p. 1115 - 1119
反应条件
in acetonitrile T=25°C; Kinetics;
参考文献
Bae, Ae Ri; Um, Ik-Hwan
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 8 p. 2719 - 2723
反应条件
1: T=100°C; P=0.2 - 1 Torr; 7 h; 2: in water; toluene T=70°C; 0.25 h; 3: With sulfuric acid; ammonia more than 3 stages;
参考文献
LABORATORIO CHIMICO INTERNAZIONALE S.P.A.
Patent: WO2005/37820 A1, 2005 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: in isopropyl alcohol T=20°C; 2: With water in dichloromethane
参考文献
Schering Aktiengesellschaft
Patent: EP1657241 A1, 2006 ;
Location in patent: Page/Page column 24-25 ;
EP 1657241 A1
参考文献
Baltzly et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 263,265
反应条件
in water T=25°C; aminolysis of O-ethyl S-aryl dithiocarbonates, pH: 9.08 - 9.68; KineticsMechanismRate constant;
参考文献
Castro, Enrique A.; Cubillos, Maria; Santos, Jose G.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6342 - 6346
反应条件
in water T=25°C; ionic strength 0.2 M (KCl), structure-reactivity correlations in the aminolysis; Rate constantMechanism;
参考文献
Castro, Enrique A.; Ureta, Carmen
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2153 - 2159
反应条件
potassium chloride; water in acetonitrile T=25°C; pH=9.08; Kinetics; Further Variations:pH-values;
参考文献
Castro, Enrique A.; Aliaga, Margarita; Gazitua, Marcela; Santos, Jose G.
Tetrahedron, 2006 , vol. 62, # 20 p. 4863 - 4869
反应条件
in acetonitrile
24 h; Heating / reflux;
参考文献
TARGEGEN, INC.
Patent: WO2006/101977 A2, 2006 ;
Location in patent: Page/Page column 102 ;
WO 2006/101977 A2
