1-(2-羟乙基)哌嗪合成路线 （共 140 条）
反应条件
sodium hydroxide; ammonia in 1,2-dichloro-ethane
T=-15 - -10°C; 0.75 h;
参考文献
Gadad, Andanappa K.; Bhat, Shailija; Tegeli, Varsha S.; Redasani, Vivek V.
Arzneimittel-Forschung/Drug Research, 2002 , vol. 52, # 11 p. 817 - 821
反应条件
1: NaI / butan-2-one / 20 h / Heating
2: 18 h / 4 °C
View Scheme
参考文献
Hirata; Peng; Driscoll
Journal of Pharmaceutical Sciences, 1978 , vol. 67, # 2 p. 157 - 162
参考文献
Ayerst, McKenna and Harrison Inc.
Patent: US4469693 A1, 1984 ;
US 4469693 A
反应条件
1: NaI / butan-2-one / 20 h / Heating
2: HCl, SOCl2 / CHCl3 / 3 h / Heating
View Scheme
参考文献
Hirata; Peng; Driscoll
Journal of Pharmaceutical Sciences, 1978 , vol. 67, # 2 p. 157 - 162
反应条件
1: 89 percent / CHCl3 / Heating
2: 72 percent / 46 percent hydrobromic acid / 5 h / Heating
View Scheme
参考文献
Valenta; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1447 - 1464
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=18 - 25°C;
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
Location in patent: Page/Page column 38 ;
反应条件
triethylamine
12 h; Heating;
参考文献
Nemeryuk, M. P.; Konstantinova, R. G.; Zukolova, S. S.; Pykhova, M. V.; Polezhaeva, A. I.; et al.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 10 p. 713 - 716
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 10 p. 1189 - 1192
反应条件
1: CHCl3 / 3 h / Heating
2: 90 percent / benzene; CHCl3; ethanol / 36 h / Ambient temperature
View Scheme
参考文献
Bartl; Svatek; Dlabac; et al.
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 8 p. 1816 - 1826
反应条件
1: CHCl3 / 3 h / Heating
2: 1.) SOCl2, C6H6, reflux 6 h; 2.) CHCl3
View Scheme
参考文献
Bartl; Svatek; Dlabac; et al.
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 8 p. 1816 - 1826
反应条件
1: 90 percent / CHCl3 / 24 h / 20 °C
2: 50 percent / DMSO; oxalyl chloride; Et3N / CH2Cl2 / -60 - 20 °C
View Scheme
参考文献
Dezi, Cristina; Brea, Jose; Alvarado, Mario; Ravina, Enrique; Masaguer, Christian F.; Loza, Maria Isabel; Sanz, Ferran; Pastor, Manuel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3242 - 3255
