1-(2-羟乙基)哌嗪合成路线 （共 140 条）
反应条件
sodium borohydride; potassium carbonate in methanol; chloroform; acetone
参考文献
Shiseido Co. Ltd.
Patent: US5814634 A1, 1998 ;
反应条件
1: T=100°C; P=0.2 - 1 Torr; 7 h;
2: in water; toluene
T=70°C; 0.25 h;
3: With sulfuric acid; ammonia
more than 3 stages;
参考文献
LABORATORIO CHIMICO INTERNAZIONALE S.P.A.
Patent: WO2005/37820 A1, 2005 ;
Location in patent: Page/Page column 8-9 ;
反应条件
hydrogen fluoride
T=7 - 8°C; Fluorination; 10.2667 h; Electrochemical reaction;
参考文献
Abe, Takashi; Fukaya, Haruhiko; Hayashi, Eiji; Ono, Taizo; Nishida, Masakazu; Soloshonok, Irina; Okuhara, Kunio
Journal of Fluorine Chemistry, 1999 , vol. 97, # 1-2 p. 229 - 237
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6172085 B2, 2001 ;
US 6172085 B1
反应条件
1.1: dichloromethane / 1 h / 20 °C
2.1: iodine; triphenylphosphine / dichloromethane / 20 h
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
3.2: 6 h / 110 °C
4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
参考文献
Wagner, Eva; Wittmann, Hans-Joachim; Elz, Sigurd; Strasser, Andrea
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6274 - 6280
反应条件
in dichloromethane
T=0°C;
参考文献
Verma, Sanjeev K.; Acharya; Kaushik
Organic Letters, 2010 , vol. 12, # 19 p. 4232 - 4235
反应条件
in water; dimethyl sulfoxide; acetonitrile
T=25°C; Kinetics;
参考文献
Jeon, Seong Hoon; Kim, Hyun Soo; Han, Young Joon; Kim, Min-Young; Um, Ik-Hwan
Bulletin of the Korean Chemical Society, 2014 , vol. 35, # 2 p. 471 - 476
反应条件
in water; dimethyl sulfoxide; acetonitrile
T=25°C; Kinetics;
参考文献
Jeon, Seong Hoon; Kim, Hyun Soo; Han, Young Joon; Kim, Min-Young; Um, Ik-Hwan
Bulletin of the Korean Chemical Society, 2014 , vol. 35, # 2 p. 471 - 476
反应条件
hydrogenchloride in dimethyl sulfoxide; acetonitrile
T=25°C; Substitution; Kinetics;
参考文献
Um, Ik-Hwan; Min, Ji-Sook; Ahn, Jung-Ae; Hahn, Hyun-Joo
Journal of Organic Chemistry, 2000 , vol. 65, # 18 p. 5659 - 5663
反应条件
potassium chloride in ethanol
T=25°C; pH=9.09; Kinetics; Further Variations:pH-valuesconcentrations;
参考文献
Castro, Enrique A.; Bessolo, Jorge; Aguayo, Raul; Santos, Jose G.
Journal of Organic Chemistry, 2003 , vol. 68, # 21 p. 8157 - 8161
