1-(2-羟乙基)哌嗪合成路线 （共 140 条）
参考文献
Journal of the American Chemical Society, , vol. 76, p. 1126,1129
US2541260 , ;
Yakugaku Zasshi, , vol. 75, p. 1367
Chem.Abstr., , p. 10106
Journal of Organic Chemistry, , vol. 8, p. 342
反应条件
hydrogen T=150 - 160°C; P=22502.3 Torr;
参考文献
WO2005/14523 A1, ;
Page/Page column 10; 11 ;
反应条件
ammonia; hydrogen T=170°C; P=150015 Torr;
参考文献
WO2005/14523 A1, ;
Page/Page column 10; 11 ;
反应条件
potassium carbonate; sodium iodide in ethanol 12 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 6 p. 2607 - 2622
反应条件
hydrogenchloride Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 9 p. 1535 - 1537
参考文献
Justus Liebigs Annalen der Chemie, , vol. 535, p. 37,45
反应条件
in chloroform T=70°C; 8 h;
参考文献
Korzycka, Lucyna
Journal of Pharmacy and Pharmacology, 2002 , vol. 54, # 3 p. 445 - 450
反应条件
sodium hydroxide T=120°C;
参考文献
Soc. Usines Chim. Rhone-Poulenc
Patent: GB807750 , 1957 ;
反应条件
in various solvent(s) T=190°C; 1.5 h; Yield given;
参考文献
Perregaard; Arnt; Bogeso; Hyttel; Sanchez
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1092 - 1101
反应条件
triethylamine in toluene Ambient temperature;
参考文献
Miyano; Tatsuoka; Suzuki; Imao; Satoh; Ishihara; Hirotsu; Kihara; Hatta; Horikawa; Sumoto
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 6 p. 1570 - 1574
