1-(2-羟乙基)哌嗪合成路线 （共 140 条）
反应条件
1: N-(2-hydroxy-ethyl)-piperazine With potassium carbonate; potassium iodide in N,N-dimethyl-formamide T=20°C; 2: 1-chloro-1,1-diphenylmethane in N,N-dimethyl-formamide T=20 - 70°C;
参考文献
Burgess, Steven J.; Kelly, Jane X.; Shomloo, Shawheen; Wittlin, Sergio; Brun, Reto; Liebmann, Katherine; Peyton, David H.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 17 p. 6477 - 6489
反应条件
in N,N-dimethyl-formamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4603135 A1, 1986 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 5 h;
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
Location in patent: Page/Page column 112-113 ;
WO 2012/059932 A1
反应条件
hydrogen fluoride T=7 - 8°C; Fluorination; 10.2667 h; Electrochemical reaction;
参考文献
Journal of Fluorine Chemistry, , vol. 97, # 1-2 p. 229 - 237
反应条件
sodium cyanoborohydride in tetrahydrofuran T=50°C;
参考文献
US2008/51397 A1, ;
Page/Page column 10; 26 ;
反应条件
hydrogenchloride; sodium hydroxide; formaldehyd; palladium monocarbide in methanol
反应条件
potassium carbonate in N,N-dimethyl-formamide; acetonitrile Microwave irradiationSealed tube;
参考文献
Farard, Julien; Loge, Cedric; Pfeiffer, Bruno; Lesur, Brigitte; Duflos, Muriel
Tetrahedron Letters, 2009 , vol. 50, # 41 p. 5729 - 5732
参考文献
Nisshin Flour Milling Co., Ltd.
Patent: US5945434 A1, 1999 ;
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Briner, Karin; Doecke, Christopher William; Mancuso, Vincent; Martinelli, Michael John; Richardson, Timothy Ivo; Rothhaar, Roger Ryan; Shi, Qing; Xie, Chaoyu
Patent: US2004/82590 A1, 2004 ;
Location in patent: Page/Page column 42 ;
US 20040082590 A1
反应条件
potassium chloride in ethanol T=25°C; pH=9.09; Kinetics; Further Variations:pH-valuesconcentrations;
参考文献
Journal of Organic Chemistry, , vol. 68, # 21 p. 8157 - 8161
