1-(2-羟乙基)哌嗪合成路线 （共 140 条）
反应条件
sodium iodide in butanone 20 h; Heating;
参考文献
Journal of Pharmaceutical Sciences, , vol. 67, # 2 p. 157 - 162
反应条件
in tetrahydrofuran 3 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/107923 A1, 2006 ;
Location in patent: Page/Page column 66 ;
反应条件
triethylamine in methanol T=20°C; 3 h;
参考文献
Hoffmann-La Roche Inc.; Hermann, Johannes Cornelius; Kuglstatter, Andreas; Lucas, Matthew C.; Padilla, Fernando; Wanner, Jutta; Zhang, Xiaohu
Patent: US2013/109661 A1, 2013 ;
Location in patent: Paragraph 0620-0621 ;
反应条件
in acetonitrile T=25°C; Kinetics;
参考文献
Kim, Min-Young; Lee, Jae-In; Um, Ik-Hwan
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 4 p. 1115 - 1119
反应条件
hydrogenchloride in water; acetonitrile T=25°C; Kinetics;
参考文献
Kang, Ji-Sun; Lee, Jae-In; Um, Ik-Hwan
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 9 p. 2971 - 2975
参考文献
Schering Corp.
Patent: US2860138 , 1956 ;
反应条件
in water T=25°C; pH 9.08 to 9.68, ionic strength 0.2 M (KCl); Rate constantMechanism;
参考文献
Castro, Enrique A.; Cubillos, Maria; Santos, Jose G.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6342 - 6346
反应条件
in water T=25°C; Kinetics;
参考文献
Lee, Jong Pal; Bae, Ae Ri; Um, Ik-Hwan
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 6 p. 1907 - 1911
反应条件
sodium hydroxide T=204°C; P=4793.91 Torr; 2.25 h; Autoclave; Product distribution / selectivity;
参考文献
Carroll, Glenn T.; Smith, Gary S.; Stringer, Gary E.
Patent: US2006/89509 A1, 2006 ;
Location in patent: Page/Page column 4-6 ;
反应条件
potassium carbonate; potassium iodide in butanone Heating;
参考文献
Grol, Cor J.; Rollema, Hans; Dijkstra, Durk; Westernik, Ben H. C.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 322 - 324
