1-(2-羟乙基)哌嗪合成路线 （共 140 条）
反应条件
triethylamine in dichloromethane
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4242507 A1, 1980 ;
反应条件
in xylene T=170°C; 12 - 18 h;
参考文献
CONCERT PHARMACEUTICALS INC.
Patent: WO2008/66620 A2, 2008 ;
Location in patent: Page/Page column 23-24 ;
反应条件
T=170°C; 5.5 h; Heating / reflux;
参考文献
UNION QUIMICO-FARMACEUTICA S.A.
Patent: WO2006/94549 A1, 2006 ;
Location in patent: Page/Page column 17-18 ;
反应条件
triethylamine in chloroform T=20°C; 2 h;
参考文献
Kumar Parai, Maloy; Panda, Gautam; Srivastava, Kumkum; Kumar Puri, Sunil
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 776 - 781
反应条件
in water; acetonitrile T=25°C; Kinetics;
参考文献
Lee, Jong Pal; Bae, Ae Ri; Im, Li-Ra; Um, Ik-Hwan
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 12 p. 3588 - 3592
反应条件
in acetonitrile T=25°C; Kinetics;
参考文献
Kim, Min-Young; Bae, Ae Ri; Um, Ik-Hwan
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 8 p. 2325 - 2329
反应条件
in acetonitrile T=25°C; Kinetics;
参考文献
Kim, Min-Young; Bae, Ae Ri; Um, Ik-Hwan
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 8 p. 2325 - 2329
反应条件
in water T=25°C; pH 9.08 to 9.68, ionic strength 0.2 M (KCl); Rate constantMechanism;
参考文献
Castro, Enrique A.; Cubillos, Maria; Santos, Jose G.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6342 - 6346
反应条件
triethylamine in chloroform T=20°C; 2 h;
参考文献
Kumar Parai, Maloy; Panda, Gautam; Srivastava, Kumkum; Kumar Puri, Sunil
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 776 - 781
反应条件
in ethanol; water T=20°C; 6.16667 h; chemospecific reaction;
参考文献
Verma, Sanjeev K.; Acharya; Kaushik
Organic Letters, 2010 , vol. 12, # 19 p. 4232 - 4235
