(2S)-2-[[4-(1,3-二氨基-5,6,6a,7,8,9-六氢嘧啶并[5,6-e]吲嗪-8-基)苯甲酰基]氨基]戊烷二酸合成路线 （共 5 条）
反应条件
sodium hydroxide in 2-methoxy-ethanol T=22°C; 3 h;
参考文献
DeGraw; Colwell; Kisliuk; Gaumont; Sirotnak
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1786 - 1789
反应条件
1: 1.) triethylamine, isobutyl chloroformate, 2.) triethylamine / 1.) DMF, 30 min, 2.) DMF, 20 h 2: 68 percent / 1.0 N NaOH / 2-methoxy-ethanol / 3 h / 22 °C View Scheme
参考文献
DeGraw; Colwell; Kisliuk; Gaumont; Sirotnak
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1786 - 1789
反应条件
1: 1.) triethylamine, isobutyl chloroformate, 2.) triethylamine / 1.) DMF, 30 min, 2.) DMF, 20 h 2: 68 percent / 1.0 N NaOH / 2-methoxy-ethanol / 3 h / 22 °C View Scheme
参考文献
DeGraw; Colwell; Kisliuk; Gaumont; Sirotnak
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1786 - 1789
反应条件
1: 75 percent / NaOH / 2-methoxy-ethanol; H2O / 1.) 22 deg C, 6 h, 2.) 5 deg C, 15 h 2: 1.) triethylamine, isobutyl chloroformate, 2.) triethylamine / 1.) DMF, 30 min, 2.) DMF, 20 h 3: 68 percent / 1.0 N NaOH / 2-methoxy-ethanol / 3 h / 22 °C View Scheme
参考文献
DeGraw; Colwell; Kisliuk; Gaumont; Sirotnak
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1786 - 1789
反应条件
1: 1.) 1 M BH3, 2.) HCl (gas) / 1.) THF, 22 deg C, 22 h, 2.) MeOH, 0 deg C 2: 75 percent / NaOH / 2-methoxy-ethanol; H2O / 1.) 22 deg C, 6 h, 2.) 5 deg C, 15 h 3: 1.) triethylamine, isobutyl chloroformate, 2.) triethylamine / 1.) DMF, 30 min, 2.) DMF, 20 h 4: 68 percent / 1.0 N NaOH / 2-methoxy-ethanol / 3 h / 22 °C View Scheme
参考文献
DeGraw; Colwell; Kisliuk; Gaumont; Sirotnak
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1786 - 1789
