sodium hydroxide in 2-methoxy-ethanol T=22°C; 3 h;

Multi-step reaction with 2 steps 1: 75 percent / NaOH / 2-methoxy-ethanol; H2O / 1.) 22 deg C, 6 h, 2.) 5 deg C, 15 h2: 1.) triethylamine, isobutyl chloroformate, 2.) triethylamine / 1.) DMF, 30 min, 2.) DMF, 20 h