4-甲基-4-哌啶甲酸乙酯合成路线 （共 4 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; Inert atmosphere;
参考文献
Sumiyoshi, Takaaki; Enomoto, Takeshi; Takai, Kentaro; Takahashi, Yoko; Konishi, Yasuko; Uruno, Yoshiharu; Tojo, Kengo; Suwa, Atsushi; Matsuda, Harumi; Nakako, Tomokazu; Sakai, Mutsuko; Kitamura, Atsushi; Uematsu, Yasuaki; Kiyoshi, Akihiko
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 2 p. 244 - 248
反应条件
1.1: N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -70 - -45 °C / Inert atmosphere 1.2: 1 h / -70 °C 2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C View Scheme
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 0.5 h; Inert atmosphere;
参考文献
Sumiyoshi, Takaaki; Enomoto, Takeshi; Takai, Kentaro; Takahashi, Yoko; Konishi, Yasuko; Uruno, Yoshiharu; Tojo, Kengo; Suwa, Atsushi; Matsuda, Harumi; Nakako, Tomokazu; Sakai, Mutsuko; Kitamura, Atsushi; Uematsu, Yasuaki; Kiyoshi, Akihiko
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 2 p. 244 - 248
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
1.2: 0.5 h / 20 °C
2.1: triethylamine / dichloromethane / 20 °C
View Scheme
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
