N,1,3-三甲基-1H-吡唑-5-胺合成路线 （共 3 条）
反应条件
1.1: 24 h / 20 °C 2.1: potassium hydroxide / acetone / 0.17 h / |Reflux 2.2: 1 h / |Reflux 3.1: potassium hydroxide / ethanol; water / 10 h / |Reflux View Scheme
参考文献
Maggio, Benedetta; Raffa, Demetrio; Raimondi, Maria Valeria; Daidone, Giuseppe
Molecules, 2013 , vol. 18, # 10 p. 13096 - 13110
反应条件
1.1: potassium hydroxide / acetone / 0.17 h / |Reflux 1.2: 1 h / |Reflux 2.1: potassium hydroxide / ethanol; water / 10 h / |Reflux View Scheme
参考文献
Maggio, Benedetta; Raffa, Demetrio; Raimondi, Maria Valeria; Daidone, Giuseppe
Molecules, 2013 , vol. 18, # 10 p. 13096 - 13110
反应条件
1: 65 percent / toluene / 3 h / Heating 2: 48 percent / diethyl ether / Ambient temperature 3: 1) aq. KOH, 2) H+ / 1) ethanol, reflux, 4.5 h, 2) pH 5, 150 deg C, 10 min View Scheme
参考文献
Migliara; Flugy; Novara; Gagliano
Farmaco, 1992 , vol. 47, # 1 p. 111 - 119
