(3,4-二甲氧基苯基)乙酰氯合成路线 （共 69 条）
反应条件
1: 80 percent / Et3N, PBr3 / CCl4 / 2 h / Ambient temperature 2: ethanol; H2O / 5 h / Heating 3: 74.2 percent / KOH / methanol; H2O / 5 h / Heating 4: oxalyl chloride / benzene / 1 h / Ambient temperature View Scheme
参考文献
Journal of the Indian Chemical Society, , vol. 66, # 8-10 p. 656 - 659
反应条件
1: ethanol; H2O / 5 h / Heating 2: 74.2 percent / KOH / methanol; H2O / 5 h / Heating 3: oxalyl chloride / benzene / 1 h / Ambient temperature View Scheme
参考文献
Journal of the Indian Chemical Society, , vol. 66, # 8-10 p. 656 - 659
反应条件
1: 84 percent / H2O / 1 h / Heating 2: 1.) 40percent formalin; 2.) KOH / 1.) methanol, 65 deg C; 2.) water, 70 deg C, 40 min, reflux, 20 min 3: 80 percent / Et3N, PBr3 / CCl4 / 2 h / Ambient temperature 4: ethanol; H2O / 5 h / Heating 5: 74.2 percent / KOH / methanol; H2O / 5 h / Heating 6: oxalyl chloride / benzene / 1 h / Ambient temperature View Scheme
参考文献
Journal of the Indian Chemical Society, , vol. 66, # 8-10 p. 656 - 659
反应条件
1: 1.) 40percent formalin; 2.) KOH / 1.) methanol, 65 deg C; 2.) water, 70 deg C, 40 min, reflux, 20 min 2: 80 percent / Et3N, PBr3 / CCl4 / 2 h / Ambient temperature 3: ethanol; H2O / 5 h / Heating 4: 74.2 percent / KOH / methanol; H2O / 5 h / Heating 5: oxalyl chloride / benzene / 1 h / Ambient temperature View Scheme
参考文献
Journal of the Indian Chemical Society, , vol. 66, # 8-10 p. 656 - 659
反应条件
1: 67 percent / dimethylsulfoxide / 20 h 2: 76.6 percent / KOH / H2O; ethane-1,2-diol / 20 h / Heating 3: SOCl2 / benzene / 2 h / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 19, # 9 p. 748 - 749
反应条件
chloroform; phosphorus pentachloride
参考文献
Chemische Berichte, , vol. 42, p. 1984
Chem. Zentralbl., , vol. 81, # I p. 1621
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 148, p. 926;
Chemische Berichte, , vol. 42, p. 1986;
Chem. Zentralbl., , vol. 81, # I p. 1621
反应条件
1: NaOH-solution 2: thionyl chloride View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , p. 7
反应条件
1: 96 percent / Et3N, DMAP / CH2Cl2 / 25 °C 2: BH3 / tetrahydrofuran / 72 h / Heating 3: 88 percent / DMAP, NEt3 / CH2Cl2 / 0 °C 4: POCl3 / benzene / Heating 5: NaBH4 / methanol / 4 h / -78 °C 6: 82 percent / H2 / Pd/C / ethanol; aq. HCl View Scheme
参考文献
Polniaszek, Richard P.; McKee, Julia A.
Tetrahedron Letters, 1987 , vol. 28, # 39 p. 4511 - 4514
参考文献
Rios-Lombardia, Nicolas; Busto, Eduardo; Garcia-Urdiales, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Journal of Organic Chemistry, 2009 , vol. 74, # 6 p. 2571 - 2574
反应条件
1: 72 percent / AlCl3 / 1.) 15 deg C, 6.5 h, 2.) R.T. overnight 2: 88 percent / NaBH4 / ethanol / 5 h / 50 - 60 °C 3: 90 percent / gaseous HCl, CaCl2 / benzene / 4.5 h / 10 - 15 °C 4: 12 percent / CHCl3 / 1.) reflux, 6 h, 2.) R.T. overnight View Scheme
参考文献
Valenta; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1447 - 1464
