(3,4-二甲氧基苯基)乙酰氯合成路线 （共 69 条）
反应条件
sodium hydroxide in chloroform T=20°C; 0.5 h;
参考文献
Hirata, Masahiko; Mori, Tetsuya; Soga, Seigo; Umeda, Takuya; Ohmomo, Yoshiro
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 4 p. 470 - 475
反应条件
1: 98 percent / AlCl3 / CH2Cl2 / 2 h / Heating 2: phosphorus pentoxide / acetonitrile View Scheme
参考文献
Makhey, Darshan; Gatto, Barbara; Yu, Chiang; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 6 p. 781 - 791
反应条件
1: 8.0 g / CH2Cl2 / 2 h / 0 - 20 °C 2: 83 percent / Lawesson's reagent / toluene / 5 h / Heating 3: 84 percent / toluene / 18 h / Heating 4: 93 percent / CF3COOH / CH2Cl2 / 48 h / 20 °C 5: 68 percent / Raney nickel / ethanol / 15 h / Heating View Scheme
参考文献
Padwa, Albert; Beall, L. Scott; Heidelbaugh, Todd M.; Liu, Bing; Sheehan, Scott M.
Journal of Organic Chemistry, 2000 , vol. 65, # 9 p. 2684 - 2695
反应条件
sodium hydroxide in chloroform 0.5 h;
参考文献
Wert, Kathleen L.; Chackalamannil, Samuel; Miller, Eric; Dalton, David R.; Zacharias, David E.; Glusker, Jenny P.
Journal of Organic Chemistry, 1982 , vol. 47, # 26 p. 5141 - 5150
反应条件
triethylamine in chloroform T=0°C;
参考文献
Martin, Ned H.; Jefford, Charles W.
Helvetica Chimica Acta, 1982 , vol. 65, # 3 p. 762 - 774
反应条件
triethylamine in hexane 1.) rt, 4 h 2.) 60 deg C, 0.5 h;
参考文献
Law, Kock-Yee; Bailey, F. Court
Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3278 - 3286
反应条件
aluminium chloride in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane
参考文献
Dr. Karl Thomae GmbH
Patent: US4584293 A1, 1986 ;
反应条件
(i) AlCl3, CH2Cl2, (ii) /BRN= 1730731/; Multistep reaction;
参考文献
Jetter, Michele C.; Youngman, Mark A.; McNally, James J.; McDonnell, Mark E.; Zhang, Sui-Po; Dubin, Adrienne E.; Nasser, Nadia; Codd, Ellen E.; Flores, Christopher M.; Dax, Scott L.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6160 - 6163
反应条件
aluminium trichloride in dichloromethane 4 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Kanao, Munefumi; Hashizume, Takeshi; Ichikawa, Yoshifumi; Irie, Kiyoshi; Isoda, Sumiro
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1358 - 1363
反应条件
1: aq. Na2CO3 / CHCl3 / 0 °C
2: POCl3 / toluene / Heating
3: tetralin / 10percent Pd/C / 220 - 230 °C
4: 1.) POCl3, 3.) aq. HCl
View Scheme
参考文献
Makhey, Darshan; Gatto, Barbara; Yu, Chiang; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 6 p. 781 - 791
