(3,4-二甲氧基苯基)乙酰氯合成路线 （共 69 条）
反应条件
1.1: ammonia / tetrahydrofuran
2.1: toluene-4-sulfonic acid / toluene / Reflux
2.2: 60 - 65 °C
View Scheme
参考文献
Gudaparthi, Vijayalakshmi; Bharathi; Panda, Jagadeesh
Asian Journal of Chemistry, 2010 , vol. 22, # 7 p. 5323 - 5330
反应条件
1: 72 percent / AlCl3 / 1.) 15 deg C, 6.5 h, 2.) R.T. overnight
2: 88 percent / NaBH4 / ethanol / 5 h / 50 - 60 °C
3: 90 percent / gaseous HCl, CaCl2 / benzene / 4.5 h / 10 - 15 °C
4: 89 percent / CHCl3 / Heating
5: 72 percent / 46 percent hydrobromic acid / 5 h / Heating
View Scheme
参考文献
Valenta; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1447 - 1464
反应条件
1: 82 percent / pyridine; toluene / 7.5 h / 60 - 70 °C
2: 1.) POCl3, P2O5, 2.) NaBH4, 5M NaOH / 1.) toluene, reflux 4 h, 2.) ethanol
View Scheme
参考文献
Valenta; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1447 - 1464
反应条件
1: 72 percent / AlCl3 / 1.) 15 deg C, 6.5 h, 2.) R.T. overnight
2: 98 percent formic acid / 12 h / 170 - 180 °C
3: 66 percent / POCl3 / toluene / 4.5 h / Heating
4: 1.) NaBH4, 5M NaOH, 2.) HCl / 1.) ethanol, reflux, 6 h, 2.) ether.
5: 95 percent / 46 percent hydrobromic acid / 6.5 h / 100 °C
View Scheme
参考文献
Valenta; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1447 - 1464
反应条件
1: 72 percent / AlCl3 / 1.) 15 deg C, 6.5 h, 2.) R.T. overnight
2: 98 percent formic acid / 12 h / 170 - 180 °C
3: 66 percent / POCl3 / toluene / 4.5 h / Heating
4: 1.) NaBH4, 5M NaOH, 2.) HCl / 1.) ethanol, reflux, 6 h, 2.) ether.
View Scheme
参考文献
Valenta; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1447 - 1464
反应条件
1: NaN3 / acetone; H2O / 4 h / 0 °C
2: benzene / 5 h / Heating
View Scheme
参考文献
Park, See-Hyoung; Kang, Sun-Hee; Lim, Sang-Hyeong; Oh, Hyun-Sik; Lee, Keun-Hyeung
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3455 - 3459
反应条件
2: P2O5 / toluene / Heating
View Scheme
参考文献
Kawai, Hiroshi; Kotake, Yaichiro; Ohta, Shigeru
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1669 - 1671
反应条件
1: diethyl ether / Ambient temperature
2: 82 percent / LAH / dioxane; diethyl ether
3: 1.) SOCl2 / 1.) benzene, reflux, 2.) ether, r.t.
4: 1.) POCl3, 2.) KI / 1.) reflux, 2.) H2O
5: NaBH4 / methanol
View Scheme
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
反应条件
1: diethyl ether / Ambient temperature
2: 82 percent / LAH / dioxane; diethyl ether
3: 1.) SOCl2 / 1.) benzene, reflux, 2.) ether, r.t.
4: 1.) POCl3, 2.) KI / 1.) reflux, 2.) H2O
5: NaBH4 / methanol
View Scheme
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
反应条件
aluminium trichloride in dichloromethane
2 h; Heating;
参考文献
Makhey, Darshan; Gatto, Barbara; Yu, Chiang; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 6 p. 781 - 791
