3,5,8-三甲基-3H-咪唑并[4,5-f]喹喔啉-2-胺合成路线 （共 5 条）
反应条件
ammonium formate; palladium on activated charcoal in methanol 120 h; Heating;
参考文献
Bierer, Donald E.; O'Connell, John F.; Parquette, Jon R.; Thompson, Charles M.; Rapoport, Henry
Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1390 - 1405
反应条件
1: H2 / Raney nickel / ethanol / 1.5 h / Ambient temperature 2: 30 percent / H2O / 0.17 h / Heating 3: 70 percent / acetic anhydride / 1 h / Ambient temperature 4: 70 percent / LiAlH4 / tetrahydrofuran / 4 h / 0 - 5 °C 5: 65 percent / conc. H2SO4, KNO3 / acetic acid / 1.) 0 deg C, 2.) 20 deg C, 90 min 6: 1.) H2 / 1.) Raney nickel / 1.) ethanol, room temperature, 60 min, 2.) room temperature View Scheme
参考文献
Nyhammar, Tomas; Grivas, Spiros
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 7 p. 583 - 587
反应条件
1: 65 percent / conc. H2SO4, KNO3 / acetic acid / 1.) 0 deg C, 2.) 20 deg C, 90 min 2: 1.) H2 / 1.) Raney nickel / 1.) ethanol, room temperature, 60 min, 2.) room temperature View Scheme
参考文献
Nyhammar, Tomas; Grivas, Spiros
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 7 p. 583 - 587
反应条件
1: 70 percent / LiAlH4 / tetrahydrofuran / 4 h / 0 - 5 °C 2: 65 percent / conc. H2SO4, KNO3 / acetic acid / 1.) 0 deg C, 2.) 20 deg C, 90 min 3: 1.) H2 / 1.) Raney nickel / 1.) ethanol, room temperature, 60 min, 2.) room temperature View Scheme
参考文献
Nyhammar, Tomas; Grivas, Spiros
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 7 p. 583 - 587
反应条件
hydrogen; nickel 1.) ethanol, room temperature, 60 min, 2.) room temperature; Yield given. Multistep reaction;
参考文献
Nyhammar, Tomas; Grivas, Spiros
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 7 p. 583 - 587
