4-[4-(二甲氨基)-1-(4-氟苯基)-1-羟丁基]-3-羟甲基苯腈氢溴酸盐合成路线 （共 3 条）
反应条件
1: 5-cyano-isobenzofuran-1-one; (4-fluoro-phenyl)-magnesium bromide in tetrahydrofuran; dichloromethane T=-5 - 5°C; 0.5 h; 2: 3-(N,N-dimethylamino)-propylmagnesium chloride in tetrahydrofuran; dichloromethane; toluene T=-5 - 5°C;
参考文献
US2010/87664 A1, ;
Page/Page column 4 ;
反应条件
1: With sulfuric acid in water T=100°C; 8 h; 2: With sodium hydroxide in water; toluene T=25 - 35°C; pH=8 - 8.5; 3: With hydrogen bromide in water; isopropyl alcohol T=0 - 20°C;
参考文献
Vedantham, Ravindra; Chinta, Raveendra Reddy; Vetukuri, Venkata Naga Kali Vara Prasada Raju; Boini, Ambaiah; Sundaraneedi, Veera Madhavi; Medisetti, Rama Krishna Venkata; Manudhane, Kushal Surajmal
Patent: US2010/87664 A1, 2010 ;
Location in patent: Page/Page column 4 ;
反应条件
sodium carbonate in water; ethyl acetate T=25 - 35°C; 0.333333 h;
参考文献
JUBILANT ORGANOSYS LTD
Patent: WO2006/106531 A1, 2006 ;
Location in patent: Page/Page column 11-13 ;
