反应条件
1: 98 percent / NaOMe / methanol / 1.25 h / 0 °C
2: xylene / 5 h / Heating; variation of time
3: 85 percent / anhydrous HCl / methanol / 12 h / 70 °C
4: 76 percent / tetrahydrofuran / 0.33 h / 22 °C
5: 81 percent / 1.) H2O2, BF3*Et2O / 3.) DMAP / 1.) CH2Cl2; 2.) CH2Cl2, 8 min, 23 deg C; 3.) CH2Cl2, 23 deg C, 18 h
6: 96 percent / LiOH / tetrahydrofuran; methanol; H2O / 1 h / 50 °C
View Scheme
参考文献
Boger,D.L.; Coleman,R.S.
Journal of the American Chemical Society, 1987 , vol. 109, p. 2717
