1: 7,8-dimethoxy-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepine With potassium tert-butylate in dimethyl sulfoxide T=20°C; 1 h; 2: 3-chloro-N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-N-methyl-1-propanamine in dimethyl sulfoxide T=20°C; Product distribution / selectivity;

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C 1.2: 20 °C 2.1: hydrogen; acetic acid / 20 palladium(II) hydroxide on carbon / ethanol / 5 h / 20 °C / 3750.38 Torr View Scheme

1: 7,8-dimethoxy-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepine With potassium tert-butylate in dimethyl sulfoxide 1.08333 h; Inert atmosphere; 2: 3-chloro-N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-N-methyl-1-propanamine in dimethyl sulfoxide T=25 - 30°C; 3: With hydrogenchloride in isopropyl alcohol; acetonitrile T=15 - 20°C; pH=1 - 2; 12 h; Inert atmosphere;

1.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 °C 1.2: 20 °C 2.1: hydrogenchloride / diethyl ether; acetonitrile View Scheme

1: 2,3-dihydro-7,8-dimethoxy-2-oxo-1H-3-benzazepine With potassium tert-butylate in dimethyl sulfoxide T=20°C; 0.5 h; 2: 3-chloro-N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-N-methyl-1-propanamine in dimethyl sulfoxide T=20°C;