3-二甲氨基-1-(萘-5-基)丙酮合成路线 (共 5 条)
反应条件
sodium hydroxide in water; toluene T=20°C; 0.416667 - 0.666667 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2006/125769 A1, 2006 ;
Location in patent: Page/Page column 20 ;
参考文献
EP2371819 A1, ;
Page/Page column 7 ;
反应条件
hydrogenchloride in methanol 2 h; Heating;
参考文献
Moawad; Yousif; Metwally
Pharmazie, 1989 , vol. 44, # 12 p. 820 - 822
反应条件
hydrogenchloride; formaldehyd; ethanol
参考文献
Journal of the American Chemical Society, , vol. 70, p. 4184
Journal of Organic Chemistry, , vol. 17, p. 313
Journal of the Chemical Society, , p. 1196,1200
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran T=-20°C; 0.25 h; Nitrogen atmosphere; 2: 6-bromo-2-methoxy-3-(phenylmethyl)-quinoline in tetrahydrofuran T=-70°C; 0.5 h; 3: 1-(α-naphthyl)-3-(N,N-dimethylamino)-1-propanone With water more than 3 stages;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2006/67048 A1, 2006 ;
Location in patent: Page/Page column 27-29 ;