2-(4-(羟基甲基)苯氧基)乙酸乙酯合成路线 （共 13 条）
反应条件
potassium carbonate in acetonitrile T=60°C; 18 h;
参考文献
Lusin, Tina Trdan; Tomasic, Tihomir; Trontelj, Jurij; Mrhar, Ales; Peterlin-Masic, Lucija
Chemico-Biological Interactions, 2012 , vol. 197, # 1 p. 8 - 15
反应条件
potassium carbonate in acetonitrile T=90°C; 2 h; Sealed tubeInert atmosphere;
参考文献
ALMIRALL, S.A.; AIGUADE BOSCH, Jose; GUAL ROIG, Silvia; PRAT QUINONES, Maria; PUIG DURAN, Carlos
Patent: WO2013/68552 A1, 2013 ;
Location in patent: Page/Page column 52; 53 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=90°C; 2 h;
参考文献
Li, Xin; Abell, Chris; Warrington, Brian H; Ladlow, Mark
Organic and biomolecular chemistry, 2003 , vol. 1, # 24 p. 4392 - 4395
反应条件
tetrabutylammomium bromide; potassium carbonate in N,N-dimethyl-formamide
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US4803211 A1, 1989 ;
反应条件
1.1: 100 percent / Amberlyst H-15 / tetrahydrofuran / 48 h / 20 °C 2.1: BH3*THF / tetrahydrofuran / 24 h / 65 °C 2.2: aq. HCl / tetrahydrofuran / 1 h / 20 °C 2.3: 84 percent / Et2NH / tetrahydrofuran / 16 h / 20 °C View Scheme
参考文献
Jawale, Dhanaji V.; Pratap, Umesh R.; Mane, Ramrao A.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 924 - 928
反应条件
1.1: SOCl2 / tetrahydrofuran 2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 2.2: 59 percent / dimethylformamide / 18 h / 20 °C View Scheme
参考文献
Lusin, Tina Trdan; Tomasic, Tihomir; Trontelj, Jurij; Mrhar, Ales; Peterlin-Masic, Lucija
Chemico-Biological Interactions, 2012 , vol. 197, # 1 p. 8 - 15
反应条件
1.1: SOCl2 / tetrahydrofuran 2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 2.2: 59 percent / dimethylformamide / 18 h / 20 °C 3.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 4.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 5.1: tetrahydrofuran 6.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme
参考文献
Lusin, Tina Trdan; Tomasic, Tihomir; Trontelj, Jurij; Mrhar, Ales; Peterlin-Masic, Lucija
Chemico-Biological Interactions, 2012 , vol. 197, # 1 p. 8 - 15
反应条件
sodium hydroxide; water in methanol
参考文献
Hidaka, Koushi; Kimura, Tooru; Ruben, Adam J.; Uemura, Tsuyoshi; Kamiya, Mami; Kiso, Aiko; Okamoto, Tetsuya; Tsuchiya, Yumi; Hayashi, Yoshio; Freire, Ernesto; Kiso, Yoshiaki
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 23 p. 10049 - 10060
反应条件
1.1: 100 percent / Amberlyst H-15 / tetrahydrofuran / 48 h / 20 °C 2.1: BH3*THF / tetrahydrofuran / 24 h / 65 °C 2.2: aq. HCl / tetrahydrofuran / 1 h / 20 °C 2.3: 84 percent / Et2NH / tetrahydrofuran / 16 h / 20 °C 3.1: 82 percent / 24 h / 120 °C 4.1: 86 percent / polymer-supported chromic acid / tetrahydrofuran / 48 h / Heating 5.1: 99 percent / piperazinomethyl polystyrene / toluene / 24 h / 88 °C View Scheme
参考文献
Jawale, Dhanaji V.; Pratap, Umesh R.; Mane, Ramrao A.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 924 - 928
反应条件
1.1: H-15 / tetrahydrofuran 2.1: borane-THF / 65 °C 2.3: SCX-2 3.1: 120 °C 4.1: PS-CrO3 / tetrahydrofuran 5.1: piperidine / toluene / 2 h / 80 °C 6.1: iodine; magnesium / methanol / 3 h / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 2 p. 924 - 928
