四氢吡喃-4-基-乙酸乙酯合成路线 （共 10 条）
反应条件
ammonium formate; palladium T=80°C;
参考文献
American Cyanamid Company
Patent: US6340691 B1, 2002 ;
Location in patent: Page column 66 ;
US 6340691 B1
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate 18 h;
参考文献
EP1019398 B1, ;
Page 44 ;
反应条件
1.1: NaH / benzene / 0.5 h / 20 °C 1.2: 92 percent / benzene / 1 h / 60 °C 2.1: 98.5 percent / hydrogen / Pd/C / ethanol / 2585.74 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 26 p. 9909 - 9911
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Targacept, Inc.
Patent: US2004/220214 A1, 2004 ;
反应条件
1: 100 percent / LiAlH4 / tetrahydrofuran / Heating 2: 77 percent / Et3N / CH2Cl2 / 16 h / 0 - 20 °C 3: 73 percent / LiBr / acetone / 5 h / Heating View Scheme
参考文献
LABORATORIOS DEL DR. ESTEVE, S.A.; DRACONIS PHARMA, S.L.; ALMIRALL, S.A.; TORRENS JOVER, Andoni; MERCÈ VIDAL, Ramon; CALDENTEY FRONTERA, Francesc Xavier; RODRÍGUEZ GARRIDO, Antonio, David; CARCELLER GONZÁLEZ, Elena; SALAS SOLANA, Jordi
Patent: WO2013/37960 A1, 2013 ;
反应条件
sodium hydroxide in ethanol 4 h;
参考文献
Ghosh, Arun K.; Thompson, Wayne J.; Holloway, M. Katharine; McKee, Sean P.; Duong, Tien T.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2300 - 2310
反应条件
1: 67 percent / LiAlH4 / tetrahydrofuran / 4 h 2: 78 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / 2 h / -60 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 23 p. 6309 - 6323
反应条件
1: petroleum ether; sodium; ethanol 2: HBr / 100 - 110 °C 3: methanol; NH3 / 140 °C View Scheme
参考文献
Prelog et al.
Justus Liebigs Annalen der Chemie, 1937 , vol. 532, p. 80
Chem.Abstr., 1940 , p. 4396
参考文献
Pandey, Karuna Shanker; Shriprakash; Rao, Karumuru Mallikarjuna; Vaidyanathaswamy, Ramamoorthy
Bioscience, Biotechnology, and Biochemistry, 1994 , vol. 58, # 4 p. 647 - 651
反应条件
1: petroleum ether; sodium; ethanol
2: HBr / 100 - 110 °C
View Scheme
参考文献
Prelog et al.
Justus Liebigs Annalen der Chemie, 1937 , vol. 532, p. 80
Chem.Abstr., 1940 , p. 4396
