7-溴-4-氯-5H-吡咯并[3,2-D]嘧啶合成路线 （共 4 条）
反应条件
1: With trichlorophosphate T=115°C; 3 h; 2: With potassium carbonate in water T=0 - 20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2008/70507 A2, 2008 ;
Location in patent: Page/Page column 153 ;
反应条件
N-bromosuccinmide in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Khoje, Abhijit Datta; Kulendrn, Aisvareya; Charnock, Colin; Wan, Baojie; Franzblau, Scott; Gundersen, Lise-Lotte
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7274 - 7282
反应条件
1: N-bromosuccinmide / N,N-dimethyl-formamide / 18 h 2: trichlorophosphate / 3 h / 115 °C View Scheme
参考文献
WO2011/113798 A2, ;
WO 2011/113798 A2
反应条件
1.1: potassium hydroxide / 40 h / Reflux 1.2: 20 °C / pH 6.5 - 7.5 2.1: trichlorophosphate / Reflux 3.1: N-bromosuccinmide / tetrahydrofuran / 1 h View Scheme
参考文献
WO2012/93809 A2, ;
WO 2012/093809 A2
