3-辛基-3-吡啶-4-基哌啶-2,6-二酮合成路线 （共 4 条）
反应条件
hydrogenchloride in water; tert-butyl alcohol
参考文献
National Research Development Corporation
Patent: US5112976 A1, 1992 ;
反应条件
1: anh.Cs2CO3 / acetonitrile / 2 h / Heating 2: Triton B / 2-methyl-propan-2-ol / 2 h 3: conc. H2SO4 / acetic acid / 3 h / Heating View Scheme
参考文献
Boss, Aileen M.; Clissold, Derek W.; Mann, John; Markson, Andrew J.; Thickitt, Christopher P.
Tetrahedron, 1989 , vol. 45, # 18 p. 6011 - 6017
反应条件
1: anh.Cs2CO3 / acetonitrile / 2 h / Heating 2: Triton B / 2-methyl-propan-2-ol / 2 h 3: conc. H2SO4 / acetic acid / 3 h / Heating View Scheme
参考文献
Leung; Rowlands; Jarman; Foster; Griggs; Wilman
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1550 - 1554
反应条件
1: 1.) potassium tert-butoxide; 2.) potassium tert-butoxide / 1.) tert-butanol, 50 deg C, 40 min; 2.) 1 h 3: 68 percent / potassium tert-butoxide / dimethylformamide / Ambient temperature View Scheme
参考文献
Boss, Aileen M.; Clissold, Derek W.; Mann, John; Markson, Andrew J.; Thickitt, Christopher P.
Tetrahedron, 1989 , vol. 45, # 18 p. 6011 - 6017
