1-苯基-4-(2-苯基乙基)哌嗪合成路线 （共 7 条）
反应条件
trifluorormethanesulfonic acid; 1,5-bis-(diphenylphosphino)-pentane; [Ru(η4-COD)(η3-methylallyl)2] in 1,4-dioxane T=100°C; 24 h;
参考文献
YALE UNIVERSITY
Patent: WO2005/77885 A1, 2005 ;
Location in patent: Page/Page column 20-21; 30 ;
反应条件
lithium carbonate in acetonitrile 24 h; RefluxInert atmosphere;
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
反应条件
[Rh(COD)(DPEphos)][BF4] in toluene T=75°C; 72 h;
参考文献
Utsunomiya, Masaru; Kuwano, Ryoichi; Kawatsura, Motoi; Hartwig, John F.
Journal of the American Chemical Society, 2003 , vol. 125, # 19 p. 5608 - 5609
反应条件
potassium carbonate in butanone T=80°C; 24 h;
参考文献
Sukalovic, Vladimir; Zlatovic, Mario; Andric, Deana; Roglic, Goran; Kostic-Rajacic, Sladjana; Soskic, Vukic
Arzneimittel-Forschung/Drug Research, 2005 , vol. 55, # 3 p. 145 - 152
反应条件
in acetonitrile T=45°C; 3 h;
参考文献
Sengmany, Stephane; Le Gall, Erwan; Le Jean, Cedric; Troupel, Michel; Nedelec, Jean-Yves
Tetrahedron, 2007 , vol. 63, # 18 p. 3672 - 3681
参考文献
Hampton; Pollard
Journal of the American Chemical Society, 1937 , vol. 59, p. 2570
反应条件
1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 2: lithium carbonate / acetonitrile / 24 h / Reflux; Inert atmosphere View Scheme
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
