(9H-芴-9-基)甲基 2-(氯羰基)吡咯烷-1-羧酸合成路线 （共 6 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide in dichloromethane 1 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 51, # 19 p. 3732 - 3734
反应条件
1.1: sodium carbonate / tetrahydrofuran; water / 48 h 1.2: pH 2 - 3 2.1: thionyl chloride / dichloromethane / 0.5 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 6 p. 613 - 618
参考文献
Ananda; Gopi; Suresh Babu
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 9 p. 790 - 795
反应条件
pyridine in tetrahydrofuran T=4°C;
参考文献
Jacobsen, Mogens Havsteen; Buchardt, Ole; Engdahl, Tom; Holm, Arne
Tetrahedron Letters, 1991 , vol. 32, # 43 p. 6199 - 6202
反应条件
pyridine in tetrahydrofuran T=4°C;
参考文献
Jacobsen, Mogens Havsteen; Buchardt, Ole; Engdahl, Tom; Holm, Arne
Tetrahedron Letters, 1991 , vol. 32, # 43 p. 6199 - 6202
反应条件
1.1: 72 percent / TEA; TBDMS-OBt / tetrahydrofuran / 20 °C
2.1: 86 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
3.1: 70 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
4.1: 81 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
5.1: 79 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
6.1: 85 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
7.1: 72 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
8.1: aq. HCOOH / Pd/C / methanol / 3 h / 20 °C
8.2: 80 percent / aq. NaHCO3 / 0.33 h
View Scheme
参考文献
Suresh Babu; Gayathri; Gopi
Synthetic Communications, 1999 , vol. 29, # 1 p. 79 - 91
