9H-芴-9-基甲基{(2S)-3-[4-(苄氧基)苯基]-1-氯-1-氧代-2-丙基}氨基甲酸酯合成路线 （共 3 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide in dichloromethane 1 h; Ambient temperature;
参考文献
Carpino, Louis A.; Cohen, Beri J.; Stephens, Kenton E.; Sadat-Aalaee, S. Yahya; Tien, Jien-Heh; Langridge, Denton C.
Journal of Organic Chemistry, 1986 , vol. 51, # 19 p. 3732 - 3734
反应条件
1: NaHCO3 / CH2Cl2 / 0.33 h 2: 58 percent / H2 / Pd/C / ethanol; ethyl acetate / 24 h / 2327.17 Torr / Ambient temperature View Scheme
参考文献
Carpino, Louis A.; Philbin, Michael
Journal of Organic Chemistry, 1999 , vol. 64, # 12 p. 4315 - 4323
反应条件
1: 85 percent / KOBt / CH2Cl2
2: 74 percent / aq. NaOH / methanol / 3 h
3: 77 percent / thionyl chloride / CH2Cl2 / 24 h
4: 76 percent / KOBt / CH2Cl2 / 0.5 h / Ambient temperature
5: 83 percent / aq. NaOH / methanol / 3 h
6: 77 percent / SOCl2 / CH2Cl2 / 24 h / Ambient temperature
7: 62 percent / KOBt / CH2Cl2 / Ambient temperature
8: 57 percent / aq. HCOOH / Pd black
View Scheme
参考文献
Suresh Babu; Gayathri; Gopi
Synthetic Communications, 1999 , vol. 29, # 1 p. 79 - 91
