(2S)-2-[[(2S)-5-氧代吡咯烷-2-羰基]氨基]丁二酰胺合成路线 （共 6 条）
反应条件
ammonia in methanol Ambient temperature;
参考文献
Gudasheva, T. A.; Ostrovskaya, R. U.; Maksimova, F. B.; Trofimov, S. S.; Kosoi, M. Yu.; et al.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 3 p. 191 - 194
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 3 p. 271 - 275
反应条件
in N,N-dimethyl-formamide T=20°C;
参考文献
Gudasheva, T. A.; Rozantsev, G. G.; Ostrovskaya, R. U.; Trofimov, S. S.; Voronina, T. A.; et al.
Pharmaceutical Chemistry Journal, 1995 , vol. 29, # 1 p. 14 - 17
Khimiko-Farmatsevticheskii Zhurnal, 1995 , vol. 29, # 1 p. 15 - 18
反应条件
n-ethyl morpholine in N,N-dimethyl-formamide T=20°C;
参考文献
Gudasheva; Trofimov; Morozova; Nikitin; Ostrovskaya; Voronina; Seredenin
Pharmaceutical Chemistry Journal, 2006 , vol. 40, # 1 p. 18 - 22
反应条件
1: dicyclohexylcarbodiimide 2: N-ethylmorpholine / dimethylformamide / 20 °C View Scheme
参考文献
Gudasheva, T. A.; Ostrovskaya, R. U.; Maksimova, F. B.; Trofimov, S. S.; Kosoi, M. Yu.; et al.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 3 p. 191 - 194
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 3 p. 271 - 275
反应条件
1: Et3N / dimethylformamide / 5 h / Ambient temperature 2: 83 percent / NH3 / methanol / Ambient temperature View Scheme
参考文献
Gudasheva, T. A.; Ostrovskaya, R. U.; Maksimova, F. B.; Trofimov, S. S.; Kosoi, M. Yu.; et al.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 3 p. 191 - 194
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 3 p. 271 - 275
反应条件
methanol; ammonia T=20°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Gudasheva, T. A.; Rozantsev, G. G.; Ostrovskaya, R. U.; Trofimov, S. S.; Voronina, T. A.; et al.
Pharmaceutical Chemistry Journal, 1995 , vol. 29, # 1 p. 14 - 17
Khimiko-Farmatsevticheskii Zhurnal, 1995 , vol. 29, # 1 p. 15 - 18
