N-BOC-2-甲基-L-脯氨酸合成路线 （共 5 条）
反应条件
tetreamethyl ammonium hydroxide in acetonitrile
72 h; Ambient temperature;
参考文献
Khalil, Ehab M.; Subasinghe, Nalin L.; Johnson, Rodney L.
Tetrahedron Letters, 1996 , vol. 37, # 20 p. 3441 - 3444
反应条件
triethylamine in 1,4-dioxane; water
5 h;
参考文献
Chu, Shao Song; Alegria, Larry Andrew; Bleckman, Ted Michael; Chong, Wesley Kwan Mung; Duvadie, Rohit K.; Li, Lin; Reich, Siegfried Heinz; Romines III, William Henry; Wallace, Michael B.; Yang, Yi
Patent: US2003/225147 A1, 2003 ;
Location in patent: Page 45 ;
反应条件
sodium hydroxide in water; N,N-dimethyl-formamide
Heating;
参考文献
Thaisrivongs; Pals; Lawson; Turner; Harris
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 536 - 541
反应条件
1: DIEA, DMAP / CH2Cl2 / 72 h / Ambient temperature
2: NaOH, H2O / methanol / 48 h
View Scheme
参考文献
Lewis, Arwel; Wilkie, John; Rutherford, Trevor J.; Gani, David
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 22 p. 3777 - 3793
反应条件
1: pentane / 168 h / Heating
2: LDA / tetrahydrofuran; hexane / 1.) -78 deg C, 1 h, 2.) -78 to -30 deg C, 2 h
3: 58 percent / SOCl2 / 2 h / Heating
4: DIEA, DMAP / CH2Cl2 / 72 h / Ambient temperature
5: NaOH, H2O / methanol / 48 h
View Scheme
参考文献
Lewis, Arwel; Wilkie, John; Rutherford, Trevor J.; Gani, David
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 22 p. 3777 - 3793
