3-氨基-5-苯基-1,3-二氢-2H-1,4-苯并二氮杂革-2-酮合成路线 （共 13 条）
反应条件
1: triethylamine; O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium*PF6(1-) / CH2Cl2 / 18 h / 20 °C
2: 26.1 g / hydrochloric acid / ethyl acetate / 3 h / -10 - 20 °C
3: 99 percent / CH2Cl2 / 18 h / 20 °C
4: 380 mg / trifluoroacetic acid / 0.67 h / 50 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ZHAO, Yufen; GAVAI, Ashvinikumar V.; GILL, Patrice; KIM, Soong-Hoon; FINK, Brian E.; CHEN, Libing; SAULNIER, Mark G.; HAN, Wen-Ching
Patent: WO2014/47397 A1, 2014 ;
Location in patent: Paragraph 00213 ;
反应条件
Berger SFC MGIII Column in methanol; carbon dioxide; diethylamine
T=40°C; Resolution of racemate; Purification / work up;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; GAVAI, Ashvinikumar V.; HAN, Wen-Ching; FINK, Brian E.; GUARINO, Victor R.
Patent: WO2014/47391 A1, 2014 ;
Location in patent: Paragraph 00166 ;
反应条件
pyridine
T=20°C; 1.5 h;
参考文献
Carter, Malcolm C.; Alber, Dagmar G.; Baxter, Robert C.; Bithell, Sian K.; Budworth, Jo; Chubb, Ann; Cockerill, G. Stuart; Dowdell, Verity C. L.; Henderson, Elisa A.; Keegan, Sally J.; Kelsey, Richard D.; Lockyer, Michael J.; Stables, Jeremy N.; Wilson, Lara J.; Powell, Kenneth L.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2311 - 2319
