(2S,3R,4E)-2-叠氮-4-十八碳烯-1,3-二醇合成路线 (共 62 条)
反应条件
trifluoromethanesulfonyl azide; potassium carbonate; copper(II) sulfate in methanol; dichloromethane; water T=30°C; 3 h;
参考文献
Schombs, Matthew; Park, Francine E.; Du, Wenjun; Kulkarni, Suvarn S.; Gervay-Hague, Jacquelyn
Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 4891 - 4898
反应条件
toluene-4-sulfonic acid in methanol; dichloromethane 14 h;
参考文献
Duclos Jr., Richard I
Chemistry and Physics of Lipids, 2001 , vol. 111, # 2 p. 111 - 138
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=25°C; 1 h;
参考文献
Nicolaou, K. C.; Caulfield, T.; Kataoka, H.; Kumazawa, T.
Journal of the American Chemical Society, 1988 , vol. 110, # 23 p. 7910 - 7912
反应条件
tetrabutyl ammonium fluoride; acetic acid in tetrahydrofuran T=0°C; 2 h;
参考文献
Van Den Berg, Richard J.B.H.N.; Korevaar, Cornelis G.N.; Van Der Marel, Gijsbert A.; Overkleeft, Herman S.; Van Boom, Jacques H.
Tetrahedron Letters, 2002 , vol. 43, # 46 p. 8409 - 8412
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 1 h;
参考文献
Kim, Sanghee; Lee, Sukjin; Lee, Taeho; Ko, Hyojin; Kim, Deukjoon
Journal of Organic Chemistry, 2006 , vol. 71, # 22 p. 8661 - 8664
反应条件
hydrogenchloride in tetrahydrofuran; water T=20°C; 30 h;
参考文献
Compostella, Federica; Franchini, Laura; De Libero, Gennaro; Palmisano, Giovanni; Ronchetti, Fiamma; Panza, Luigi
Tetrahedron, 2002 , vol. 58, # 43 p. 8703 - 8708
反应条件
CuSO4‵5H2O; potassium carbonate in methanol T=20°C; 12 h;
参考文献
Sandbhor, Mahendra S.; Key, Jessie A.; Strelkov, Ileana S.; Cairo, Christopher W.
Journal of Organic Chemistry, 2009 , vol. 74, # 22 p. 8669 - 8674
反应条件
1: 59 percent / (PhO)2P(O)N3; DIAD; PPh3 / toluene / 12 h / 20 °C 2: 82 percent / p-TsOH / methanol / 12 h / 20 °C View Scheme
参考文献
Chemical communications (Cambridge, England), , # 5 p. 426 - 427
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 1 h;
参考文献
Somfai, Peter; Olsson, Roger
Tetrahedron, 1993 , vol. 49, # 30 p. 6645 - 6650
反应条件
sodium methylate in methanol 2 h; Ambient temperature;
参考文献
Kumar, Pradeep; Schmidt, Richard R.
Synthesis, 1998 , # 1 p. 33 - 35