7-氟-6-硝基-2H-苯并[b][1,4]噁嗪-3(4H)-酮合成路线 （共 3 条）
反应条件
nitric acid in sulfuric acid
参考文献
Valent U.S.A. Corporation
Patent: US5108488 A1, 1992 ;
反应条件
1: potassium carbonate / acetonitrile / 1 h / |Inert atmosphere; |Reflux 2: ammonium chloride; iron / water; methanol / 2 h / 80 °C 3: sulfuric acid; nitric acid / 0.5 h / 0 °C / |Inert atmosphere View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish
Patent: WO2013/153539 A1, 2013 ;
反应条件
1: ammonium chloride; iron / water; methanol / 2 h / 80 °C 2: sulfuric acid; nitric acid / 0.5 h / 0 °C / |Inert atmosphere View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish
Patent: WO2013/153539 A1, 2013 ;
