7-氟-2H-1,4-苯并恶嗪-3(4H)-酮合成路线 (共 10 条)
反应条件
hydrogen; palladium monocarbide in ethanol
反应条件
iron; acetic acid 2.5 h; Inert atmosphereReflux;
参考文献
Tetrahedron, , vol. 67, # 6 p. 1187 - 1192
反应条件
iron; ammonium chloride in methanol; water T=80°C; 2 h;
参考文献
WO2011/151361 A1, ;
Page/Page column 40-41 ;
WO 2011/151361 A1
反应条件
in tetrahydrofuran; acetonitrile T=70°C; 6 h;
参考文献
WO2009/71895 A1, ;
Page/Page column 96 ;
WO 2009/071895 A1
反应条件
in acetic acid; ethyl acetate
反应条件
N-ethyl-N,N-diisopropylamine in ethylene glycol dimethyl ether T=80°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 16 p. 4700 - 4704
反应条件
1: potassium carbonate / acetone / Inert atmosphere; Reflux 2: iron; acetic acid / 2.5 h / Inert atmosphere; Reflux View Scheme
参考文献
Tetrahedron, , vol. 67, # 6 p. 1187 - 1192
反应条件
borane in tetrahydrofuran T=80°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 16 p. 4700 - 4704
反应条件
nitric acid in sulfuric acid
参考文献
Valent U.S.A. Corporation
Patent: US5108488 A1, 1992 ;
反应条件
N-bromosuccinmide in acetonitrile T=20°C; 5 h;
参考文献
UCB PHARMA S.A.
Patent: WO2009/71895 A1, 2009 ;
Location in patent: Page/Page column 96 ;
WO 2009/071895 A1