S-Boc-β-苯丙氨酸合成路线 （共 30 条）
反应条件
1: Na2CO3, Et3N / methanol / 1 h / 65 °C 2: CCl4, PPh3 / 4 h / 80 °C 3: 1.) n-BuLi, LiC10H7 / 1.) THF, hexane, -78 deg C, 3 h, 2.) THF, hexane, from -78 to 20 deg C, overnight View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 10 p. 2911 - 2922
反应条件
1: CCl4, PPh3 / 4 h / 80 °C 2: 1.) n-BuLi, LiC10H7 / 1.) THF, hexane, -78 deg C, 3 h, 2.) THF, hexane, from -78 to 20 deg C, overnight View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 10 p. 2911 - 2922
反应条件
1: 92 mg / Et3N / 1 h / 0 °C 2: 92 percent / aq. LiOH / methanol; tetrahydrofuran / 1 h / 0 - 20 °C View Scheme
参考文献
Synlett, , # 12 p. 2039 - 2040
反应条件
1: 4-DMAP / CH2Cl2 2: 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine 3: 1.) 9-BBN, 2.) H2O2, NaOH / 1.) THF 4: PDC / dimethylformamide View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 10 p. 1589 - 1592
反应条件
1: 1.) 9-BBN, 2.) H2O2, NaOH / 1.) THF 2: PDC / dimethylformamide View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 10 p. 1589 - 1592
反应条件
1: H2/PdCl2 / methanol / 1 h 2: toluene / 2 h / Heating 3: DMAP / CH2Cl2 / 2 h / Ambient temperature 4: dimethylsulfoxide / 1 h / 90 °C 5: 2N NaOH / ethanol / 3 h / 90 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 34 p. 4539 - 4542
反应条件
1: CF3CO2H / CH2Cl2 / 1.5 h / Ambient temperature 2: H2/PdCl2 / methanol / 1 h 3: toluene / 2 h / Heating 4: DMAP / CH2Cl2 / 2 h / Ambient temperature 5: dimethylsulfoxide / 1 h / 90 °C 6: 2N NaOH / ethanol / 3 h / 90 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 34 p. 4539 - 4542
反应条件
1: toluene / 2 h / Heating 2: HIO4 / methanol / 1 h / 0 °C 3: NaBH4 / methanol / 1 h / Ambient temperature 4: CF3CO2H / CH2Cl2 / 1.5 h / Ambient temperature 5: H2/PdCl2 / methanol / 1 h 6: toluene / 2 h / Heating 7: DMAP / CH2Cl2 / 2 h / Ambient temperature 8: dimethylsulfoxide / 1 h / 90 °C 9: 2N NaOH / ethanol / 3 h / 90 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 34 p. 4539 - 4542
反应条件
1: dimethylsulfoxide / 1 h / 90 °C 2: 2N NaOH / ethanol / 3 h / 90 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 34 p. 4539 - 4542
反应条件
1: HIO4 / methanol / 1 h / 0 °C 2: NaBH4 / methanol / 1 h / Ambient temperature 3: CF3CO2H / CH2Cl2 / 1.5 h / Ambient temperature 4: H2/PdCl2 / methanol / 1 h 5: toluene / 2 h / Heating 6: DMAP / CH2Cl2 / 2 h / Ambient temperature 7: dimethylsulfoxide / 1 h / 90 °C 8: 2N NaOH / ethanol / 3 h / 90 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 34 p. 4539 - 4542
