3-羟基-2-氧代-1,2,3,4-四氢喹啉-7-甲腈合成路线 （共 3 条）
反应条件
1: With sodium tetrahydroborate in acetonitrile T=22 - 24°C; 1 h; 2: With iron; acetic acid in acetonitrile T=65°C; 2 h;
参考文献
Reck, Folkert; Alm, Richard A.; Brassil, Patrick; Newman, Joseph V.; Ciaccio, Paul; McNulty, John; Barthlow, Herbert; Goteti, Kosalaram; Breen, John; Comita-Prevoir, Janelle; Cronin, Mark; Ehmann, David E.; Geng, Bolin; Godfrey, Andrew Aydon; Fisher, Stewart L.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 15 p. 6916 - 6933
反应条件
1.1: ethanol / 16 h / 20 °C 2.1: sodium tetrahydroborate / acetonitrile / 1 h / 20 °C 2.2: 1 h / 70 °C View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
1.1: sulfuric acid; nitric acid / 1 h / 0 - 20 °C 2.1: ethanol / 16 h / 20 °C 3.1: sodium tetrahydroborate / acetonitrile / 1 h / 20 °C 3.2: 1 h / 70 °C View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
