4-苯基-1,2,3,6-四氢吡啶合成路线 （共 22 条）
反应条件
1: Pd(OAc)2 2: HCl 3: NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 22 p. 3951 - 3954
反应条件
hydrogenchloride; ammonium chloride 1.) MeOH, 40 deg C, 20 h, 2.) 100 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chemische Berichte, , vol. 118, # 2 p. 551 - 559
参考文献
Journal of the American Chemical Society, , vol. 78, p. 1702,1704
参考文献
Journal of the Chemical Society, , p. 1143,1147
反应条件
triethylamine in benzene 1 h; Heating;
参考文献
Grigg; Santhakumar; Sridharan; Stevenson; Teasdale; Thornton-Pett; Worakun
Tetrahedron, 1991 , vol. 47, # 46 p. 9703 - 9720
反应条件
aluminum oxide; palladium/alumina; nitrobenzene T=130°C;
参考文献
Schmidle; Mansfield
Journal of the American Chemical Society, 1956 , vol. 78, p. 1702,1704
反应条件
aluminum oxide; palladium/alumina; ethanol T=70°C; P=73550.8 Torr; Hydrogenation;
参考文献
Boggiano et al.
Journal of the Chemical Society, 1959 , p. 1143,1147
反应条件
aluminium trichloride T=60°C; 1 h;
参考文献
Schaefer; Hackmack; Eistetter; Krueger; Menge; Klosa
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 3 p. 233 - 240
反应条件
hydrogen bromide; acetic acid
参考文献
Boggiano et al.
Journal of the Chemical Society, 1959 , p. 1143,1147
反应条件
1: 4-phenyl-1,2,3,6-tetrahydro-pyridine With potassium carbonate in butanone
T=20°C; 0.5 h;
2: ethyl 4-bromobutanoate in butanone
5 h; Heating / reflux;
参考文献
NEUROCHEM (INTERNATIONAL) LIMITED
Patent: WO2004/113275 A2, 2004 ;
Location in patent: Page 171 ;
